CCL24 Protein (AA 27-119)

N° du produit ABIN2666899

Cette protéine Recombinant CCL24 est produite dans Escherichia coli (E. coli).

Aperçu rapide pour CCL24 Protein (AA 27-119) (ABIN2666899)

Antigène: CCL24 (Chemokine (C-C Motif) Ligand 24 (CCL24))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Escherichia coli (E. coli)

Application: Western Blotting (WB)

Pureté: > 98 % , as determined by Coomassie stained SDS-PAGE.

Détail du produit

Attributs du protein: AA 27-119

Stérilité: 0.22 μm filtered

niveau d'endotoxine:

Less than 0.01 ng per μg cytokine as determined by the LAL method.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Biological activity: Bioactivity was measured by its property to chemoattract BaF3-mCCR3 transfectants in a dose dependent manner.

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10 μg/mL in sterile buffer (PBS, HPBS, DPBS, and EBSS) containing carrier protein such as 1 % BSA or HSA. After dilution, the cytokine can be stored between 2 °C and 8 °C for one month or from -20 °C to -70 °C for up to 3 months.

Buffer: 0.22 μm filtered protein solution is in PBS.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: Unopened vial can be stored between 2°C and 8°C for three months, at -20°C for six months, or at -70°C for one year.

Détail du antigène

Antigène: CCL24 (Chemokine (C-C Motif) Ligand 24 (CCL24))

Autre désignation: CCL24

Sujet: CLL24 was initially cloned from a library of activated macrophages, and using human eosinophils, it was shown that it binds to the receptor of eotaxin-1 (CCL11) and MCP-4 (CCL13). In addition, CCL24 shares the CCR3 receptor with CCL26, CCL5, and CCL7. Eotaxin/CCR3 expression has been studied extensively in the pathogenesis of asthma and allergy. In addition, the eotaxin/CCR3 axis has been associated to additional inflammatory and autoimmune disorders including inflammatory bowel disease, multiple sclerosis, eosinophilic esophagitis, and rheumatoid arthritis. CCL24 has also been associated to neovascular age related macular degeneration.

Poids moléculaire: The 93 amino acid recombinant protein has a predicted molecular mass of approximately 10.4 kDa. The DTT-reduced protein migrates at approximately 12 kDa and non-reduced protein migrates at 14 kDa by SDS-PAGE. The N-terminal amino acid is Valine.

Pathways: Regulation of Actin Filament Polymerization